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Natural Vet Shawn Messonnier, Natural Vet, shares his knowledge about pets and how to maintain their health. Articles on this page include: Vaccines…A Holistic Approach to a Common Medical Procedure
The most commonly performed medical procedure for pet cats is annual immunization. For
many years this has been a standard practice and recommendation. Over the last few years,
new information has come to light that has caused us to question the validity of this
recommendation. Research has shown that most cats can mount an immune response to vaccination that lasts longer than 12 months; in some instances vaccines have produced immunity lasting many years. As a result, many veterinarians have recommended vaccinating cats every 3 years rather than annually. But is this recommendation the best one? Is it possible that a better vaccine protocol would be more suitable for your cat? Does every cat even need any vaccines? This article will explore the topic of immunization and present a holistic alternative that has worked well in my practice. While the recommendation for annual immunization has been the standard of practice for many years, there is really no scientific basis for it. Because there are potential short term and long term These simple blood tests can give us information about an individual pet's antibody status in relation to specific diseases. In simple terms, antibodies are proteins made by the pet's white blood cells (specifically B lympho0cytes.) These antibodies are made whenever a pet contacts an infectious organism (virus or bacteria, as a result of a natural infection) or is vaccinated (the vaccine uses low doses of infectious organisms, tricking the immune system to form protective antibodies without causing disease as might occur in a natural infection.) Using a titer test reveals each pet's antibody status. These results are then interpreted in an attempt to determine if the pet is currently protected against a specific infectious disease or if the pet may require immunization. There are both pros and cons to the use of vaccine (antibody) titers to determine the need to immunize pets. Pros: Cons: Following injection, inflammation results (usually as a result of the adjuvant in the medication or
vaccine; the adjuvant is a chemical added to increase local inflammation and a more intense immune
reaction.) The amount of chronic inflammation occurring at the site of the injection is related to the cat's
risk of developing injection site sarcoma (the more inflammation the greater the risk.) Since vaccines
are often given annually in the same site on the cat's body, it is no surprise that risk increases with the
number of vaccines given in 1 site.
Not all cats will develop injection site sarcoma as a result of an injection (most cats do not develop
injection site sarcomas despite inflammation at the injection site.) Apparently there is some interaction
between intense inflammation and tumor oncogenes which ultimately results in tumor formation follow-
ing injections. In fact, preliminary research has shown that sarcomas associated with vaccines had
overexpression of the c-jun gene (a gene that is related to cancer development in animals species (an
oncogene),) when compared to sarcomas not related to vaccine injection. The working hypothesis as
to why some rare cats develop injection site sarcomas (and most cats do not) is that something in the
injections (probably adjuvant) causes persistent inflammation at the injection site, which in some way
stimulates the cat's oncogenes to overreact and develop tumors. In other words, it appears that some
cats may be genetically predisposed to developing injection site sarcomas, and the inflammation
following immunization is the trigger to set this reaction in motion.
When vaccinosis occurs, holistic doctors may prescribe a homeopathic or herbal detoxification proto-
col. Many doctors use the homeopathic remedy Thuja to minimize side effects from vaccines.
In summary, I believe the best recommendations for determining how to handle the “vaccination contro-
versy) at this point are as follows:
*While not perfect, titers are the only inexpensive way to assess each pet's unique vaccine needs.
*Standardized testing should be adopted, along with an agreed upon "correct" level to constitute a
protective titer (this may be difficult, as each vaccine manufacturer would need to determine the "correct"
level for each vaccine produced.)
*Any titer indicates the ability of the pet to respond to immunization. The higher the titer, the greater the
antibody level at the time of the testing. As long as the pet has protective immunity, however, vaccines
are not needed as they do not "boost" the immune system.
*Until we have more information, we probably need to use published studies by vaccine manufacturers
showing the levels of titers that afforded vaccinated puppies and kittens protection from disease
challenge.
At this time, most holistic veterinarians use a combination of blood titers plus their knowledge of the pet's
lifestyle. For example, an outdoor cat is at higher risk of coming in contact with cats that may transmit
infectious diseases. The need for this cat to be adequately immunized is greater than the cat that never
leaves the house except to go for a veterinary visit 1-2 times each year and has little chance of ever con-
tracting an infectious disease. In order to maximize your cat’s ability to withstand infection and disease, a
strong immune system (maintained by a healthy diet supplemented with quality nutritional supplements)
is of paramount importance.
Pets with chronic immune disorders (cancer, allergies, epilepsy, kidney disease, heart disease, liver
disease, thyroid disease, etc.) may be at increased risk for further immune damage from the unnecessary
use of chemicals such as flea products, preservatives in most commercial pet foods, and vaccines. While
controversial, most holistic doctors, including myself, recommend never administering vaccines to pets
with any chronic, serious disorder, especially those involving the immune system.
Pets with mild problems (such as well controlled allergies) can probably be vaccinated safely if their
allergies are under control and titer testing indicates a need for vaccination. This is an individual decision
as many disorders seem to appear shortly after immunization, and chronic disorders may be exacerbated
(more itching in allergic pets, more seizures in an epileptic pet, etc.) following immunization. While rare,
pets in remission following a diagnosis of cancer have been known to relapse following immunization; as
a rule, most doctors do not recommend ever revaccinating pets with cancer. Pets undergoing stress
(illness) should not be immunized. Cats who have experienced vaccine reactions, as well as those whose
closely-related family members have a documented clinical illness following immunization should
probably not be over-vaccinated, and possibly not vaccinated at all.
The following recommendations seem prudent for pets that must receive vaccinations (extrapolated from
Rivera P. Vaccinations and Vaccinosis,
Journal AHVMA, Feb-Apr 1997, Vol 16, No 1:19-24.)
1.Only immunize healthy pets.
2.Shedding of viral particles can occur in the feces of pets vaccinated with modified-live viruses. These
pets should not be exposed to sick pets or unvaccinated pets for at least 2-3 weeks following immunization.
3.Consider the animal's lifestyle when deciding when to immunize and which vaccines to immunize (what
diseases is the pet most likely to encounter considering its lifestyle.)
4.Don't let vaccines substitute for proper medical care (good diet, supplements, prevention of disease via
regular dental cleanings and necessary laboratory testing.)
5.Don't vaccinate pregnant animals.
6.Don't vaccinate animals during their estrus (heat) cycles.
While controversial, there is a definite need to minimize immunizations in pets (and I also believe in people,
particularly children.) Using vaccine titers as part of a health maintenance program will help achieve this
goal and keep your pet healthy (for a free copy of my health maintenance protocol, email me at naturalvet
@j juno.com. I can only respond to emails.)
Skinning the Cat: Understanding the Basics of Feline Skin Disease
Skin disorders are among the most common problems seen in small animal practice. While we usually
think of dogs as the species having a lot of dermatology problems, cats also have skin disorders as well.
This article will cover the basics of diagnosing and treating skin disease in cats.
Treating dogs with skin disease is usually pretty easy. A number of disorders (mange, ringworm,
staphylococcal bacterial infections, autoimmune diseases) often present with typical appearances. This
means that simply looking at the pet allows the doctor to formulate a differential diagnosis of possible
causes and treatments. Unfortunately, the exact opposite is true with most cat skin problems:they all look
alike! Cat skin typically reacts in one of only 3 ways to most insults. The first is a condition called military
dermatitis, where tiny crusted bumps resembling millet seeds (hence the term military dermatitis) form all
over the cat’s skin (but typically over the back of the neck and back of the cat’s body.) The second reac-
tion is called alopecia, which simply means hair loss. Partial or complete loss of hair (usually arising from
the cat pulling the hair out because the cat itches but it can also arise from the hair actually falling out) is
the second common skin pattern seen in cats. Finally, eosinophilic lesions (fiery pink or red circular
lesions or patches) can occur as well.
Depending upon the practice location, a differential diagnosis can be made in some cases. For example,
at my practice in Plano, Texas, any cat with military dermatitis, hair loss, or eosinophilic lesions is pre-
sumed to have some type of allergic disease until proven otherwise. Cats in my practice that do not
respond to allergy treatment (using herbs, homeopathics, and minimal conventional medications) require
diagnostic testing to determine the exact cause of the dermatitis and the correct therapy.
Diagnostic testing varies with the severity of the disease, response to prior therapy, and the nature of the
cat. In my practice, the following tests are often needed to allow me to properly diagnose my patients’
skin problems. A skin scraping is used to determine if mange, caused by a microscopic parasite, is
present. A fungal culture to check for ringworm (more common in kittens, cats with underlying diseases
like leukemia and FIV, and in cats treated over long periods of time with corticosteroids) may also be
performed. Speaking of immune diseases like feline leukemia virus infection and feline immunodeficiency
virus infections, a complete blood profile should be run on all cats with chronic skin disease. Finally, cats
whose skin disease still defies diagnosis at this point must have a surgical skin biopsy performed. In this
procedure, the cat is lightly anesthetized and 3-5 tiny pieces of skin are removed.
The pieces are examined by a pathologist who can usually (about 99% of the time) give us the correct
diagnosis and help formulate the proper therapy.
Once the proper diagnosis is made, a treatment plan can be developed. It is beyond the scope of this
article to discuss treatments for skin disorders in any depth. However, the following comments should be
made as they apply to all cats with skin disease, especially chronic skin disease.
*Feeding the proper diet is the foundation upon which any treatment begins. Simply put, your cat is what
he/she eats. Minimizing harmful byproducts and chemicals, which offer little nutrition to the cat and can
be harmful, is essential. As a result, feeding the most natural diet is the best way to go. Your holistic
veterinarian can provide a recommendation about which diet is best. Several diets I like include Nature’s
Variety, Eagle Pack, California Naturals, Innova, Wysong, Old Mother Hubbard, and Halo.. Alternatively,
you may wish to prepare food at home for your pet. You can find several diets in my book The Natural
Health Bible for Dogs & Cats.
*Minimize vaccines-New research has shown that most pets do not need annual vaccines. Also, some
cats can develop cancer (fibrosarcoma) at the site of repeated immunizations. An alternative approach to
“annual shots” that has worked well in my practice is to use an annual blood antibody test called a titer
test to determine if and when your pet might need vaccinations. And regardless of the titer, I never vac-
cinate a cat until the skin disease has healed as I don’t want to interfere with my treatment.
*Minimize toxins-It is important that we reduce our pets’ chances of becoming infected with parasites,
including heartworms, intestinal worms, and external parasites such as fleas and ticks. While I believe that
oral monthly heartworm preventive medication is important, even for cats (unfortunately I have not found
any proven natural preventives,) most
pets do NOT need annual chemical flea and tick control (Frontline, Advantage, Advantix, Revolution,
Program, etc.) In my practice I discuss each pet’s need for parasite control and prefer natural therapies
when needed.
*Basic Health Maintenance Supplement-I believe all cats should receive at least a basic health mainten-
ance formula as a regular supplement. My other therapies (herbs, homeopathics, nutritional supplements)
are added to this basic supplement. The best product I have found is a product made by PetCentrx called
Vim & Vigor Formula (www.pettogethers.net/healthypet ) In addition to the vitamins and minerals your cat
requires, it contains other ingredients to support the immune system and connective tissues of the body.
It also contains L-tryptophan, an amino acid which helps ensure restful sleep at night and reduces itching
in many of my allergic patients.
*All allergic pets can also benefit from omega-3 fatty acids (fish oil) and a good antioxidant (I’ve had great
success with products made by RX Vitamins for Pets called Ultra EFA and Animal Health Options called
Proanthozone.) Other supplements are added to the treatment protocol depending upon the exact cause of
the disease and your cat’s response to therapy.
Finally, drug therapy has a place in the treatment of cat skin disorders when indicated and used properly.
The safest way to use medication is to use the lowest effective dose possible, and try to wean the cat off
the drug (when possible) as soon as feasible.
While diagnosing and treating skin disease in cats can be challenging, following the guidelines presented
in this article will make things a lot easier!
Canine distemper is a viral disease affecting dogs of all ages, but mainly unvaccinated or partially vac-
cinated puppies. Interestingly, distemper virus is related to measles virus of people. Using this knowledge,
very young puppies may be vaccinated with a modified measles virus that allows some protection against
distemper. Depending upon location and vaccination status of the population, it is either a common
disease or a rarely seen disease. In my practice, which is located in an affluent area of town, it is very rare
for pets to develop distemper. Having said this, because I practice holistic care I see more cases of dis-
temper than I would otherwise, as owners desperately seek some type of help for
pets with what is commonly a universally fatal disease. Other than referrals for these cases, the most
common pets in whom I see distemper are puppies adopted from the pound or purchased at local flea
markets. Usually these pets have had no medical care and are likely to be infected with a variety of ail-
ments (distemper, parvo virus, various parasites.)
Distemper is transmitted by direct contact between a non-infected puppy and an infected animal. Contact
with respiratory (nasal, eye) secretions and discharge transmits the virus. The severity of the disease and
the tissues infected vary with the particular strain of the virus infecting the pet and the pet's immune
system; pets with antibody titers over 1:100 typically do not develop the disease. Typical clinical signs
resemble those of kennel cough in the early stages of the disease, namely runny eyes and a runny nose.
As the disease progresses, the pet develops a thicker purulent (pus) discharge of the eyes and nose, and
develops a cough due to pneumonia. Foaming at the mouth can occur as secretions accumulate in the
throat. Lack of appetite, fever, and general lethargy also occur. Occasionally secondary skin infections
arise and resemble pimples on the abdominal skin. The pads of the feet may thicken and become hard
(distemper is often referred to as "hard pad" disease.)
Neurological complications, usually chomping of the jaw or seizures, develops later in the disease and is
often the reason most pets with distemper are euthanized.
Conventional Therapy:
There is no treatment for distemper, and most pets are euthanized once seizures develop. Supportive
care includes antibiotics, force feeding, anticonvulsants, and fluid therapy.
Natural Treatments:
Natural therapies (herbs, homeopathics, and glandular supplements) are designed to support the pet’s
immune system and help it fight off the virus. Natural therapies are usually combined with conventional
therapies to help stabilize the pet. While I have had some cures using this integrative approach, I still tell
owners that curing distemper is difficult and does not commonly occur. Still, I always believe in trying to
help this pets and since I can’t judge which pets will respond to my integrative approach, I believe
treatment should be tried on all pets.
Homeopathic Nosodes
Nosodes, a special type of homeopathic remedy, are prepared from infectious organisms such as dis-
temper virus. They can be used as a homeopathic “vaccine” or as part of the therapy for distemper. The
actual ingredients used in the nosode are diluted in such a way that no measurable amount of the original
source (virus) for the remedy remains; rather, only the vital energy of the original virus remains. Therefore,
no harm will come to your pet regardless of the virulence of the original compound used in the prepara-
tion of the nosode.
Preventing distemper is important in minimizing the number of infected animals within any location.
Homeopathic nosodes may be helpful, but definitive proof of their effectiveness is debatable. As a result, I
caution owners who choose this route for prevention. I prefer a series of immunizations, usually beginning
at 6-8 weeks of age and lasting until 16 weeks of age, to minimize disease in younger puppies. Additionally,
I also recommend that owners not allow puppies to socialize with other pets with questionable medical
history.
As a holistic veterinarian, I believe too many pets receive vaccinations that are not needed. I administer one
additional distemper vaccine at 12-18 months of age, and then do a blood antibody test called a titer test
beginning at 2-2 ½ years of age. I only immunize adult dogs for distemper if the titer test is low. Otherwise,
protective antibodies are present and additional vaccination is not needed and is possibly harmful.
To prevent disease, nosodes are supposed to work in the same manner as conventional vaccines, namely
by stimulating antibodies to fight off infections. Nosodes have been reported to control outbreaks of
infectious disease in animals in a kennel situation. While good controlled studies are lacking, homeo-
pathic veterinarians have reported success in some patients when treating infectious disease with the
homeopathic nosode.
Rabies or Distemper?
While some owners might be tempted to suspect rabies in a sick puppy, especially one that has foam
coming from the mouth and is seizuring, rabies is extrememly rare in pets. Transmission of the rabies
virus requires a bite from an infected animal, usually a wild animal. There is no cure for rabies and diag-
nosis requires microscopic examination of the brain of the infected animal. Rabies is transmissible to
people whereas distemper is not. However, distemper can be transmitted to other dogs and pet ferrets.
In conclusion, distemper virus infection is a severe and usually fatal disease most often seen in young
puppies. Vaccination is extremely effective in preventing distemper in most pets. Treatment, using an inte-
grative approach, works best but true cures are still uncommon. Because it is impossible to predict which
pets might recover, an integrative treatment approach should be offered to all patients.
RESULTS OF A CLINICAL TRIAL USING 2 NOVEL HA SUPPLEMENTS Osteoarthritis is the most common cause of skeletal disease and lameness in older dogs. Most older dogs, especially large breed dogs, will develop osteoarthritis of one or more joints. Typically, the joints that will be affected include the thoracic and lumbar vertebrae, hips, and knees. Conventional therapies for the treatment of osteoarthritis are aimed at reducing pain and inflammation,
which in turn decreases lameness and increases range of motion of the affected joints. Corticosteroids
such as prednisone and non-steroidal anti-inflammatory medications (NSAIDS)such as carprofen and
etodolac are commonly prescribed, and NSAIDS are among the most among the most prescribed medica-
tions for pets and people with osteoarthritis. While effective, conventional medications have a number of
side effects, including further damage to the joint cartilage, liver disease, kidney disease, GI disease,
weight gain, diabetes, adrenal gland disorders, and osteoporosis.
In a search to find a safer, more natural alternative to treat osteoarthritis, a number of companies have successfully marketed various joint supplements. These include glucosamine, chondroitin, shark cartilage, MSM, perna, and various anti-inflammatory herbs. Recently, two new joint supplements con- taining hyaluronic acid (hyaluronan) have been developed and released to the veterinary community. This article details clinical testing of these supplements. The two products tested were Glycovet and Cholodin-Flex, available through MVP Laboratories in Omaha,
Nebraska. Each contained xxx amount of Hyaluronan. The Glycovet is a viscous gel, and the Cholodin-
Flex is a flavored, chewable pill. The Glycovet gel is a multiplex of very specific oligomers of hyaluronan
such that they are absorbed through the mucous membranes of the mouth. The longer the dog can retain
the liquid in the mouth, the better the results. This is why it is suggested to put the gel on food or a treat.
The hyaluronan in the products comes from a fermentation of a bacterium that secretes the hyaluronan
into the media.
The proposed mechanisms of action of hyaluronan are as follows. First, HA reduces swelling at the site of
injury by decreasing leukocyte transmigration and infiltration into the affected tissue. It does this by
binding to the CD44 binding site on the leukocytes. If there is enough hyaluronan available to bind to the
CD44 sites on the leukocytes, there will be fewer leukocytes will getting to the site of trauma, resulting in
reduced swelling and pain. Secondly, HA inhibits the arachidonic acid pathway. Bradykinin is produced
by serine proteases (tissue kallikreins) cleaving high and low molecular weight kininogens. Hyaluronan
blocks the serine protease activity so that lysyl bradykinin, bradykinin and arachidonic acid cannot be
produced, resulting in decreased pain.
Subjects were obtained via a weekly newspaper column soliciting dogs with arthritis. Prior to entry into
the study, the dogs were given a physical examination to rule-out neurological disease. In some cases,
prior radiographs were evaluated to assess cartilage damage. In many cases, no prior radiographs were
available. The diagnosis of osteoarthritis was made in these patients based upon history, clinical signs,
ruling out other causes of lameness, and prior response to either corticosteroids or NSAIDS. In some
cases, dogs were currently taking NSAIDS or another joint supplement. If the patient response to the
NSAIDS or joint supplements was excellent (100% better,) the pet was taken off of the NSAID or joint
supplement at the start of the study in order to properly assess the product being tested. If the response
was less than 100% (the owner stated that the pet still exhibited lameness,) the medication or other sup-
plement was continued and the Glycovet or Cholodin-Flex was administered; the pet was monitored to
see if the residual lameness improved even further (100% response) on the new supplement.
Pets were chosen to receive either the Glycovet gel or the Cholodin-Flex tablets. Older dogs with any signs of cognitive disorder were administered the tablets (which contained choline, which has been shown to improve signs of cognitive disorder;) the other participants were administered the gel which contains only the HA without choline. Thirteen dogs received the gel, and thirty nine received the tablets. The initial dose of the gel was3-5 drops twice daily regardless of weight, and the tablets were dosed at ½ tablet twice daily for dogs 25 pounds of weight and under, and 1 tablet twice daily for dogs over 25 pounds. Owners were instructed to double the dose after 2 weeks if no improvement was noted. Following the 4 week trial, owners were contacted by telephone and asked to answer the following 4
questions:
1.What previous course of therapy had been used, and how effective was the therapy?
2.In your opinion, was this case mild, moderate/routine, or severe?
3.How would you rate your pet’s improvement with this new supplement:excellent, very good, good,
moderate, slight, or no change?
4.Would you use this supplement again?
The results of the study are as follows:
For pets taking the gel formulation, all owners questioned would use the supplement again for their pets.
Three pets were judged by the owners to have severe disease, and seven pets were judged to have
moderate or routine disease. Three owners did not respond to followup phone calls.
Response to the gel was considered moderate by 4 owners, good by 5 owners, and excellent by 1 owner.
Interestingly, several owners indicated that the pets experienced only poor to fair response to prior
therapy by administration of an NSAID.
For pets taking the tablet form which also contains choline, four owners would not use the supplement again as they saw no response to the therapy. Fourteen pets were judged by the owners to have severe disease, two pets were judged to have mild disease, and ten pets were judged to have moderate or rou- tine disease. Thirteen owners did not respond to followup phone calls. Response to the gel was con- sidered slight by 4 owners, moderate by 4 owners, good by 3 owners, very good by 6 owners, and excellent by 5 owners. As with the administration of the gel, several owners indicated that the pets experienced only poor to fair response to prior therapy by administration of an NSAID. Based upon owner observations, it appears that administration of either the Glycovet gel or Cholodin-
Flex chewable tablets was effective in controlling symptoms of lameness and pain seen in dogs with
osteoarthritis. The overall rate of success for both products based upon owner response to followup
phone calls was 28 /36 or 77% (success defined as at least a moderate improvement in the dog’s symp-
toms compared to either no treatment or other therapy prior to starting the supplement.)
As the clinical testing revealed, both the Glycovet and Cholodin-Flex were effective in treating osteo-
arthritis in dogs. Either product is a suitable, safe alternative to the use of corticosteroids or NSAIDS in
the treatment of this common chronic and disabling condition.
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